Benzene

Toxicity to terrestrial arthropods

Administrative data

Endpoint:

toxicity to terrestrial arthropods, other

Remarks:

toxicity to non-target arthropods on natural substrate (NTA other than pollinators

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Detailed information covering the calculation model, compositional data used as input, validity, applicability and adequacy of the result are in the attached document (Attached justification).
The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. The TLM, and HC5, have been applied to soils and sediment using equilibrium partitioning (EqP) model. This framework utilizes organic carbon partition coefficients (Koc) to convert aquatic based effect levels (CW) to bulk soil- and sediment-based effect levels. The combined TLM-EqP framework was validated previously for soil and sediment acute and chronic toxicity endpoints. The registered substance is within the scope of the TLM and EqP frameworks.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Refinement and validation of TLM-derived HC5 values. Independent review.

Author:

McGrath JA, Di Toro DM, Fanelli CJ

Year:

2015

Bibliographic source:

HDR, Mahwah, NJ

Reference 2

Reference Type:

publication

Title:

Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments

Author:

Redman AD, Parkerton TF, Paumen ML, McGrath JA, den Haan K, DiToro DM

Year:

2014

Bibliographic source:

Environmental Toxicology and Chemistry, 33: 12, pp. 2679-2687.

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

The target lipid model (McGrath et el., 2015) and equilibrium partitioning model (Redman et al., 2014) as described in the cited references were used to determine soil effect levels of the registered substance. A detailed explanation of the calculation method is provided in the 'Attached justification'.
For detailed model description and justification of QSAR prediction: see fields 'Justification for type of information' and 'Attached justification'.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzene

EC Number:

200-753-7

EC Name:

Benzene

Cas Number:

71-43-2

Molecular formula:

C6H6

IUPAC Name:

benzene

Test material form:

not specified

Details on test material:

Common name: Benzene
No other data provided

Test organisms

Test organisms (species):

Folsomia candida

Animal group:

Collembola (soil-dwelling springtail)

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

28 d

Dose descriptor:

LC50

Effect conc.:

29.278 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Effect concentrations 2

Duration:

28 d

Dose descriptor:

EC10

Effect conc.:

5.609 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The TLM-EqP predicted 28-day effect values for Benzene were 29.278 and 5.609 mg/kg soil dw for short-term (LC50) and long-term effects (EC10), respectively.

Executive summary:

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted 28-day effect values for Benzene were 29.278 and 5.609 mg/kg soil dw for short-term (LC50) and long-term effects (EC10), respectively.