Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Results from recent repeat dose inhalation studies suggest that ethylene may cause mild respiratory tract irritation, with very slight or slight rhinitis observed histologically at exposures of 10 ppm (11.47 mg/m3); only minor increases in severity were apparent at higher exposures (up to 10,000 ppm). These (and similar) effects have not been reported in humans making the relevance of these findings in rodents of questionable relevance to human health. With regard to systemic effects, a clear inhalation NOAEC of 10,000 ppm (11,473 mg/m3) has been identified in the rat. Whilst ethylene has been shown to have anaesthetic properties (at concentrations of 80%, equivalent dose 800,000 ppm or 917,857 mg/m3), the effect is at exposure levels which far exceed worker exposure levels. In these circumstances, a DNEL for ethylene is not being proposed.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

Results from recent repeat dose inhalation studies suggest that ethylene may cause mild respiratory tract irritation, with very slight or slight rhinitis observed histologically at exposures of 10 ppm (11.47 mg/m3); only minor increases in severity were apparent at higher exposures (up to 10,000 ppm). These (and similar) effects have not been reported in humans making the relevance of these findings in rodents of questionable relevance to human health. With regard to systemic effects, a clear inhalation NOAEC of 10,000 ppm (11,473 mg/m3) has been identified in the rat. Whilst ethylene has been shown to have anaesthetic properties (at concentrations of 80%, equivalent dose 800,000 ppm or 917,857 mg/m3), the effect is at exposure levels which far exceed consumer exposure levels. In these circumstances, a DNEL for ethylene is not being proposed.