Registration Dossier

Administrative data

Endpoint:
toxicity to non-target arthropods on natural substrate (NTA other than pollinators)
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Refinement and validation of TLM-derived HC5 values. Independent review.
Author:
McGrath JA, Di Toro DM, Fanelli CJ
Year:
2015
Bibliographic source:
HDR, Mahwah, NJ
Reference Type:
publication
Title:
Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments
Author:
Redman AD, Parkerton TF, Paumen ML, McGrath JA, den Haan K, DiToro DM
Year:
2014
Bibliographic source:
Environmental Toxicology and Chemistry, 33: 12, pp. 2679-2687.

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The endpoints calculated are the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene
EC Number:
200-815-3
EC Name:
Ethylene
Cas Number:
74-85-1
Molecular formula:
C2H4
IUPAC Name:
ethylene

Sampling and analysis

Analytical monitoring:
not required

Test organisms

Test organisms (species):
Folsomia candida
Animal group:
Collembola (soil-dwelling springtail)

Study design

Study type:
other: QSAR Calculation

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
28 d
Dose descriptor:
other: LL50
Effect conc.:
29.31 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
28 d
Dose descriptor:
other: NOELR
Effect conc.:
5.52 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Executive summary:

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted 28-day effect values for ethylene were 29.31 and 5.52 mg/kg soil dw for short-term (LL50) and long-term effects (NOELR), respectively.