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EC number: 233-135-0 | CAS number: 10043-01-3
See the attached document for tables of results
Study was conducted to determine the tissue reactions to subcutaneous and intracutaneous injections and to percutaneous application of a variety of aluminum salts.
Aluminum salts were administered as follows:
Subcutaneous (0.5 mL), using the skin of the rabbit's back; intracutaneous (0.1 mL), using the skin on the inner aspect of the rabbit's ear; percutaneous using cotton pads saturated with test solution and held to the skin of the rabbit’s ear by Scotch tape. The three basic routes of administration were modified further by being applied to intact undamaged skin, damaged skin and finally by repeated applications.
Aluminum chlorohydroxide complex, 22 %: Subcutaneous - 110 mg; intracutaneous - 22 mg
Aluminum sulfate, 17 %: Subcutaneous - 85 mg; intracutaneous - 17 mg
Acute inflammatory reactions with tissue necrosis and ulceration were noted in association with the subcutaneous and intracutaneous injection of the aluminum compounds. There was a more marked reaction at the injection sites in areas that had been previously injured. Repeated injections, either subcutaneously or intracutaneously, resulted in the same type of cutaneous ulcers, but these were not felt to be more severe than those following the original injections. Granulomas were seen only after the subcutaneous injection of aluminum chlorohydroxide complex. All lesions went on to normal, although delayed, healing. The percutaneous application of these chemical compounds failed to produce any significant lesions.
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