Registration Dossier
Registration Dossier
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EC number: 215-609-9 | CAS number: 1333-86-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Inhalation Toxicology of Urban Ambient Particulate Matter: Acute Cardiovascular Effects in Rats.
- Author:
- Vincent R et al
- Year:
- 2 001
- Bibliographic source:
- Research Report no. 104: Inhalation Toxicology of Urban Ambient Particulate Matter: Acute Cardiovascular Effects in Rats. Health Effects Institute. October 2001.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Carbon black
- EC Number:
- 215-609-9
- EC Name:
- Carbon black
- Cas Number:
- 1333-86-4
- Molecular formula:
- C
- IUPAC Name:
- carbon
- Test material form:
- solid: pellets
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 4 - <= 4 h
- Concentrations:
- 4.6 mg/m3
- Control animals:
- not specified
Results and discussion
- Preliminary study:
- LC0 (4-hour)=4.6 mg/m3
no mortality, no signs of acute toxicity were observed
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- >= 4.6 - <= 4.6 mg/m³ air
- Based on:
- not specified
- 95% CL:
- >= 0 - <= 0
- Exp. duration:
- 4 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- Carbon black is not classified as acute inhalation toxicant.
- Executive summary:
no detected mortality or signs of toxicity
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