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Diss Factsheets
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EC number: 203-497-4 | CAS number: 107-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge was collected from the Cambridge Wastewater Treatment Facility, Cambridge, Maryland on March 30, 2009. The Cambridge facility treats predominantly residential wastes.
- Preparation of inoculum for exposure: The sludge was sieved using a 2-mm screen and then aerated at test temperature until its adjustment. The activated sludge was diluted in test medium to approximately 30 mg total suspended solids/L and aerated with CO2-free air until its adjustment. The inoculated medium used in the test was prepared by diluting the preconditioned activated sludge in test medium to 4 mg total suspended solids/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
TEST SYSTEM
- Culturing apparatus: glass serum bottles with a nominal volume of 160 mL. The chambers were sealed with butyl rubber septa and crimp caps.
SAMPLING
- Sampling frequency: Replicate chambers from the control, reference and treatment groups were removed for IC analysis once a week over the test period. Replicate chambers from the toxicity control group were removed for IC analysis on Days 1 and 28. Three replicate test chambers from each group were analysed at each respective sacrifice interval, except for the last interval (5 replicates each).
- Sampling method: Samples for analysis were prepared by converting CO2 to carbonate. One millilitre of 7M NaOH was injected into the test chambers, which were subsequently shaken for at least 1 hour at test temperature. After mixing, the chambers were removed from the shaker table, allowed to settle and then samples were removed for IC analysis.- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Test substance: -3.7% in 28 days
Reference substance: 96.5% in 28d (>60% in 7 days)
Toxicity control: 46.2% in 28d - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Biodegradation of 0% in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Table 1: Inorganic carbon concentration (mg C/l) and calculated % biodegradation for inoculum blank, reference substance, test substance and toxicity control
Type of suspension |
1d |
7d |
14d |
21d |
28d |
|
|||||
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Cumulative average(%) biodeg(Day 28) |
|
|
|
|
|
|
|
|
|
|
|
||
Inoculum Blank |
- |
- |
0.3; 0.1; 0.4 |
- |
2.3; 2.4; 1.8 |
- |
2.9; 2.8; 3.1 |
- |
2.8; 2.8; 3.1; 2.6; 3.1 |
- |
- |
|
|
|
|
|
|
|
|
|
|||
Reference substance |
- |
- |
16.9; 16.8; 17.4 |
83.8; 83.4; 86.1 |
18.8; 19.5; 19.1 |
84.1; 87.4; 85.4 |
20.5; 20.4; 20.4 |
88.4; 88.2; 88.2 |
22.1; 22.0; 22.2; 21.9; 21.9 |
96.7; 96.3; 97.5; 96.1; 95.8 |
96.5 |
|
|
|
|
|
|
|
|
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Test substance |
- |
- |
0.1; 0.0; 0.0 |
-0.7; -1.3; -1.5 |
1.9; 2.3; 1.5 |
-1.5; 0.4; -3.2 |
2.4; 2.3; 2.4 |
-2.9; -3.2; -2.6 |
2.2; 2.2; 2.4; 2.1; 2.0 |
-3.5; -3.7; -2.6; -3.9; -4.6 |
-3.7 |
|
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|
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Toxicity control |
13.4; 13.6; 13.6 |
33.7; 34.3; 34.4 |
- |
- |
- |
- |
- |
- |
21.3; 21.1; 21.1; 21.4; 20.9 |
46.6; 46.0; 45.9; 46.8; 45.5 |
46.2 |
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Description of key information
Biodegradation in water: screening tests: 0% in 28 days (OECD 310)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Biodegradation of 0% in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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