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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other above-ground organisms

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The lowest NOEC for mammals refers to a full chronic study for mammals (Morris et al. 1938), which resulted in a NOEC value of 64 mg Pb/kg ww.Sub-chronic and chronic studies for 3 different mammal species were collected from literature, ie for Rattus sp. (different strains), Rattus norvegicus and for mice. For mammal oral toxicity the values varied between 64 and >12800 mg/kg ww. The lowest value of 64 mg Pb/kg ww was used to derive the PNEC, which was observed in several experiments with the Osborn-Mendel rat. According to the guidance, the PNECoral was calculated from the lowest NOECoral using an assesment factor.

An assessment factor of 6 has been selected on the lowest toxicity data. Considering a background concentration of 1.3 mg Pb/kg in the food, the PNECoral can be calculated as:PNECoral= (NOEC +Cb)/AF = (64+1.3)/6 =10.9 mg/kg food (mammal). This value is further used for risk characterisation purposes.