Ammonium acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Potassium Acetate which shares the same functional group with Ammonium Acetate, also has comparable values for the relevant molecular properties for the acute oral toxicity endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: read-across

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from published experimental data (non-standard method) on the analogue Potassium Acetate.

GLP compliance:

no

Test type:

other: read-across from a non-standard study with an analogue

Test material

Test material information

Constituent 1

Reference substance name:

Potassium acetate

EC Number:

204-822-2

EC Name:

Potassium acetate

Cas Number:

127-08-2

Molecular formula:

C2H4O2.K

IUPAC Name:

potassium acetate

Details on test material:

- Name of test material (as cited in study report): Potassium acetate
- Molecular formula (if other than submission substance): C2H4O2.K
- Molecular weight (if other than submission substance): 98.142
- Smiles notation (if other than submission substance): [K+].[O-]C(C)=O
- InChl (if other than submission substance): 1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

2.55 other: g/kg bw

Based on:

test mat.

95% CL:

1.95 - 3.35

Other findings:

Based on the experimental results obtained with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg bw) and the molecular weights, the read-across approach is applied and the LD50 for substance Ammonium Acetate is calculated to be 2.55 (1.95-3.35) g/kg bw.

The analogue Potassium Acetate which shares the same functional group with Ammonium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -3.72 for Potassium Acetate and -2.79 for Ammonium Acetate,
- a similar water solubility which is 2.5 g/mL at 20 ºC for Potassium Acetate and 1480 g/L at 4 ºC for Ammonium Acetate, and
- similar molecular weights which are 98.14 for Potassium Acetate and 77.08 for Ammonium Acetate.

Any other information on results incl. tables

The LD50 for substance Ammonium Acetate is calculated to be 2.55 (1.95-3.35) g/kg bw.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 for substance Ammonium Acetate is calculated to be 2.55 (1.95-3.35) g/kg bw.

Executive summary:

Based on the experimental results obtained (reported under the endpoint record 07.02.01_01 KAc) with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Ammonium Acetate is calculated to be 2.55 (1.95 -3.35) g/kg bw.