Alcohols, C12-14, ethoxylated

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro cytogenicity / chromosome aberration study in mammalian cells

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Justification for type of information:

Please refer to the category justification provided in the category object.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C12-14, ethoxylated

EC Number:

500-213-3

EC Name:

Alcohols, C12-14, ethoxylated

Cas Number:

68439-50-9

Molecular formula:

n.a.

IUPAC Name:

Alcohols, C12-14, ethoxylated, < 2.5 EO

Results and discussion

Test results

Key result

Species / strain:

Chinese hamster Ovary (CHO)

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

cytotoxicity

Vehicle controls validity:

valid

Untreated negative controls validity:

valid

Positive controls validity:

valid

Any other information on results incl. tables

For a detailed assessment of the potential of Alcohol Ethoxylates (AE) to induce cytogenicity / chromosome aberration, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Conclusions:

Applying read-across based on grouping of substances (category approach), no potential to induce cytogenicity / chromosome aberration in mammalian cells with and without metabolic activation is predicted for the target substance.

Executive summary:

The available data on cytotoxicity / chromosome abberation in mammalian cells in the Alcohol Ethoxylates (AE) category indicate no potential for the target substance to exhibit any mutagenic activity. As explained in the category justification, the differences in molecular structure and composition between the target substance and the members of the AE category are unlikely to lead to differences in the mutagenic potential.