Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid

Short-term toxicity to aquatic invertebrates

Description of key information

EC50 (48h) = 49 mg/L (measured) for Daphnia magna (OECD 202, read across)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

49 mg/L

Additional information

No studies investigating the short-term toxicity of Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid to aquatic invertebrates are available. Thus, available data for the source substance l-Glutamic acid, N-coco acyl derivs., monosodium salts (CAS No. 68187-32-6) was used in a read across approach. The read across approach is considered valid since l-Glutamic acid, N-coco acyl derivs., monosodium salts is structurally very similar to the main component of the multiconstituent substance only differing in the length of the carbon side chain. Whereas the length of the carbon side chain of l-Glutamic acid, N-coco acyl derivs., monosodium salts may vary between C6 to 18, the carbon side chain of L-Glutamic acid, N-(1-oxooctadecyl)-, monosodium salt is C18 only. As the relevant physico-chemical properties (log Kow < 1, water solubility = high) are similar which assumes identical environmental behavior and as molecules with shorter carbon side chains are expected to be up taken more easily into organisms, the source substance can be considered as worst case scenario for assessing the ecotoxicity of the main component of Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid.

The read across key study was performed according to GLP and OECD guideline 202 using Daphnia magna as test organism (Laus, 2011). Nominal concentrations between 2.2 and 100 mg/L were tested over a period of 48 h. Thus, a 48h-EC50 is determined to be 49 mg/L based on the measured test concentration.