Registration Dossier
Registration Dossier
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EC number: 234-290-7 | CAS number: 11070-44-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The potential of bioaccumulation of tetrahydromethylphthalic anhydride (MTHPA) is low.
Key value for chemical safety assessment
- BCF (aquatic species):
- 20.9 L/kg ww
Additional information
1. The calculated log Pow of 2.38-2.51 does not indicate that tetrahydromethylphthalic anhydride (MTHPA) might bioaccumulate. Therefore, no bioaccumulation study is conducted.
2. This assumption is supported by the BCF of MTHPA estimated by a QSAR calculation. According to QSAR (BCFBVA ver.3.0), the BCF of the test substance (MTHPA) is in the range of 17.16 -20.9 L/kg.
As MTHPA is rapidly hydrolysed to the corresponding dicarboxylic acids, a QSAR calculation of the BCF of the hydrolysis product of MTHPA was conducted in addition. The potential of bioaccumulation of the two isomers of tetrahydromethylphthalic acid is low, as calculated by QSAR given by a BCF of less than 3.2.
Therefore it is concluded that the potential of bioaccumulation of MTHPA is low.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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