Registration Dossier
Registration Dossier
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EC number: 240-521-2 | CAS number: 16470-24-9
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
The category members are not a methaemoglobin inducing agent.
The category members are not phototoxic.
Additional information
Methaemoglobin: The test compound (CAS 13863 -31 -5) has been found to be devoid of Methaemoglobin-inducing capacity after single oral administration of 5000 mg/kg in young adult rats.
It is concluded that these negative finding can also be transferred to the stilbenes which where not tested.
Phototoxicity: There were six studies done to determine wether the test substances could produce an augmented acute response of skin to a single ultraviolet light exposure (CAS 13863 -31 -5, 27344 -06 -5, and 16090 -02 -1. The results of pretreatment with the test substance were compared with pretreatment by a known phototoxic agent, 8 -methoxypsoralen (8 -MOP) or the vehicle using the skin of hairless mice, miniature pigs, and man. The test substance was not phototoxic in any species.
All these tests consistently yielded negative results indicating that Stilbene fluorescent whitening agents have no phototoxic potential. It is concluded that these negative findings can also be transferred to the stilbenes which were not tested.
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