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EC number: 226-939-8 | CAS number: 5567-15-7
The submission substrance was tested in zebrafish (Danio rerio) for 96 hours in a static system.
The test was performed with GLP compliance and following relevant guidelines with reliability category 1.
The nominal concentration tested was 100 mg/L and a control (0 mg/L).
A nominal concentration of 100 mg/L was used for the preparation of a test solution at maximum saturation of the test substance. After treatment with ultrasonic waves for approx. 30 minutes the preparation was stirred for approximately 4 days to ensure that the solubility limit of the test substance in the test water was reached. The resulting dispersion was pre-filtered through a cellulose filter followed by filtration through a membrane filter of 0.45 µm pore size.
The tested concentration was visually present as clear solution. Analytical monitoring of the concentration of the test substance in the test water was not conducted since no relevant results could be expected. The solubility limit of the test substance was below the analytical detection limit. From the properties of the test substance it could be concluded that the test substance is chemically stable in water over the test interval of 96 hours.
In this 96-hour acute toxicity study the 100 mg/L group showed no effect in comparison to the control. In the control group no effects were observed.
Under the conditions of this test the LC50 of the submission substance after 96 hours was > 100 mg/L (based on nominal concentration) and is far above the solubility limit of the test substance in the test water.
Under the conditions of this test the LC50 of the submission substance after 96 hours was > 100 mg/L (based an nominal concentration) and is above the solubility limit of the test substance in the test water.
Three acute toxicity studies of reliability 1 for Pigment Yellow 83, and its structural analogues, Pigment Yellow 12 and 170 on Danio rerio and Oncorhynchus mykiss are available. As could be expected from a grouping approach, for all three pigments of the Diarylide Yellow group consistently no toxicity towards fish has been found in any of these OECD 203 studies with nominal concentrations well above the solubility limit (0.4 μg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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