Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Valid method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report Date:
2005

Materials and methods

Principles of method if other than guideline:
Determination of solubility in octanol and calculation of log Pow with water solubility reported in section 4.8
Type of method:
other: calculation
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
1
Temp.:
24 °C
pH:
ca. 7
Type:
log Pow
Partition coefficient:
0.02
Temp.:
24 °C
pH:
ca. 7
Details on results:
Pow and log Pow were calculated from equilibrium concentrations in octanol (see below) and in water (see section 4.8)

Any other information on results incl. tables

The solubility in octanol was determined to be 8.5 µg/L at 24-25°C. This figure represents the mean of 5 determinations (range: 5.9 -11.59 µg/L, sigma = 2.19). The solubility in water was determined to be 8.1 µg/L (section 4.8)

These solubilities (equilibrium concentrations considering the tests performed) are used to calculate Pow with the following equation:

Pow = equilibrium concentration in octanol / equilibrium concentration in water

Pow = 8.5 µg/L / 8.1 µg/L

Pow = 1.0

log Pow = 0.02

Applicant's summary and conclusion

Conclusions:
The test substance has a log Pow of 0.02.
Executive summary:

The log Pow of the test substance was calculated from the equilibrium concentrations in water and in octanol. The log Pow at 24 °C (24 -25 °C for octanol, 23 -24 °C for water) was 0.02.