Registration Dossier
Registration Dossier
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EC number: 217-007-1 | CAS number: 1719-58-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- No guideline is specified; a relatively brief report is given. The neat material was applied the intact belly skin of rabbits for 15 or 30 seconds, 1 or 2 minutes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chlorodimethylvinylsilane
- EC Number:
- 217-007-1
- EC Name:
- Chlorodimethylvinylsilane
- Cas Number:
- 1719-58-0
- Molecular formula:
- C4H9ClSi
- IUPAC Name:
- chloro(dimethyl)vinylsilane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 15 seconds, 30 seconds, 1 minute, 2 minutes
- Observation period:
- as above - no further details
- Number of animals:
- not stated - possibly one
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: slight erythema and oedema
- Time point:
- other: 15 seconds
- Irritation parameter:
- other: slight erythema, necrosis and scab formation
- Time point:
- other: 30 seconds
- Irritation parameter:
- other: moderate to marked necrosis probably resulting in scar formation
- Time point:
- other: 1 minute
- Irritation parameter:
- other: marked necrosis probably resulting in deep scar formations
- Time point:
- other: 2 minutes
Applicant's summary and conclusion
- Conclusions:
- A limited report of a study without guideline or GLP compliance recorded slight necrosis and marked necrosis to rabbit skin, following contact for 15 seconds and 2 minute, respectively, with the neat material.
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