Registration Dossier
Registration Dossier
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EC number: 217-007-1 | CAS number: 1719-58-0
Endpoint summary
Administrative data
Description of key information
Chloro(dimethyl)vinylsilane is a chlorosilane, generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin and eye irritation studies (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin. The limited experimental data available on skin and eye irritation/corrosion (DCC, 1969) support the above comments on the corrosive nature of this material.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Chloro(dimethyl)vinylsilane hydrolyses rapidly in contact with water and moist air, releasing one mole of hydrogen chloride (HCl) for each mole of parent material. Although the irritation/corrosion studies available are limited, their findings support the severe skin, eye and respiratory damage that would be expected due to release of HCl.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is a non-standard, non-GLP study. Nevertheless it clearly demonstrates the corrosive nature of the test substance.
Justification for selection of eye irritation endpoint:
The selected study is a non-standard, non-GLP study. Nevertheless it clearly demonstrates the corrosive nature of the test substance.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Chloro(dimethyl)vinylsilane is classified 'Skin Corr. 1A' with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008. The additional hazard statement 'EUH071 Corrosive to the respiratory tract' (1272/2008/EC) is proposed, in accordance with related chlorosilane substances and the findings of a limited acute inhalation study, and based on the expected respiratory tract damage caused by the hydrolysis product HCl.
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