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EC number: 908-918-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The acute toxicity was examined following oral administration of various amounts of primary amyl acetate to male and female rats. Rats were observed for up to 14 days post-dosing. A gross pathological examination was performed on each rat.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of 2-methylbutyl acetate and pentyl acetate
- EC Number:
- 908-918-1
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction mass of 2-methylbutyl acetate and pentyl acetate
- Details on test material:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
Clear, non-viscous liquid. No additional information available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hilltop-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals are maintained on appropriate commercial diet and municipal water. Both are available ad libitum except during periods of fasting (rat peroral test), manipulation or restraint.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Hilltop-Wistar albino rats, weighing between 200 and 300 g, receive the test material by stomach intubation with a ball-end stainless steel needle. The
sample is injected through the needle by means of a syringe and doses are varied by adjusting the volume of the test material or its dilution. The rats are fasted overnight before dosing. Five males and 5 females are included on each level. - Doses:
- 4.0, 8.0 and 16.0 ml/kg for males and 4.0, 8.0, 11.3 and 16.0 ml/kg for females (corresponding to 3502.4, 7004.8 and 14009.6 mg/kg for males and 3502.4, 7004.8, 9894.3 and 14009.6 mg/kg for females, calculated assuming a test substance density of 0.8756 g/ml)
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- Groups of 5 male or female rats were weighed and dosed with undiluted primary amyl acetate. Survivors were weighed 7 and 14 days post-dosing. Animals were observed for 14 days post-dosing. Animals that died or survived were subjected to a gross necropsy examination.
- Statistics:
- LD50's are calculated by the moving average method (Thompson, 1947) and are based on a 14-day observation period.
Reference
Thompson, W.R. (1947). Use of moving averages and interpolation to estimate median-effective dose. Bact. Reviews 11:115.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 7 004.8 - < 14 009.6 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated from 8 and 16 ml/kg
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 12 258.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 10 594.8 - 14 272.3
- Remarks on result:
- other: calculated from 14 ml/kg (12.1 - 16.3 ml/kg)
- Mortality:
- Male rats
2/5 died one day after dosing with 16.0 ml/kg
0/5 died following dosing with 4.0 or 8.0 ml/kg
Female rats
4/5 died one day after dosing with 16.0 ml/kg
0/5 died after dosing with 4.0, 8.0 or 11.3 ml/kg - Clinical signs:
- other: Male rats dosed with 16.0 ml/kg: Sluggishness, unsteady gait at 45 min; lacrimation, slow respiration prostration at 4 hr. Survivors recovered at 2 days. No clinical signs noted in male rats dosed with 4.0 or 8.0 ml/kg. Female rats dosed with 16.0 ml/kg
- Gross pathology:
- Male rats
16.0 ml/kg: In victims, 1 with liver blanched, intestines green; 1 with hydronephrosis. In survivors, nothing remarkable.
8.0 ml/kg: Nothing remarkable.
4.0 ml/kg: Nothing remarkable.
Female rats
16.0 ml/kg: In victims, livers blanched red discoloration on peri-nasal fur of 1. In survivor nothing remarkable.
11.3 ml/kg: Lungs mottled dark red and red.
8.0 ml/kg: Nothing remarkable.
4.0 ml/kg: Nothing remarkable. - Other findings:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 for male and female rats is >16.0 and 14.0 ml/kg, respectively.
- Executive summary:
The acute oral toxicity of primary amyl acetate was examined in rats. The oral LD50 for male and female rats is >16.0 and 14.0 ml/kg, respectively.
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