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Alkanes and alkenes are types of organic functional groups that are generally resistant to hydrolysis (Harris JC and Hayes MJ (1990). Rate of hydrolysis. In: Handbook of Chemical Property estimation Methods: Environmental Behaviour of Organic Compounds. Lyman WJ, Reehl WF and Rosenblatt DH (eds.), American Chemical Society, Washington DC, USA.). A hydrolysis rate constant was estimated for a surrogate analogue (CF3-CHF-CH3) [421-48-7] using the alkyl halides QSAR within HYDROWIN v2. With an estimated half-live in the range 106 to 107 years, the hydrolysis rate of this molecule without the double bond, is expected to be negligible. The presence of the -CF=CH2group in HFO-1234yf, instead of the -CHFCH3group in [421-48-7] for which the calculation was done, is not expected to have a major influence on the hydrolysis rate. Therefore, based on this structure-activity relationship, hydrolysis is not expected to be a relevant degradation mechanism for this substance.