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disregarded due to major methodological deficiencies

Data source

Reference Type:
In vitro sorption of aluminum complex to guinea pig stratum corneum
Putterman, G.J., Strassburger, J., Fitzgerald, J.J.
Bibliographic source:
The Journal of Investigative Dermatology, 77:319-324, 1981

Materials and methods

Test material


Results and discussion

Applicant's summary and conclusion

Executive summary:

The sorption of Al complexes to guinea pig stratum corneum has been studied using previously described fluorometric and atomic absorption spectrophotometric procedures. The sorption, desorption, and binding properties of the two aluminum systems most often used in topically applied antiperspirants, aluminum chloride and aluminum chlorohydrate, Al2(OH)5Cl.2H2O were examined as a function of aluminum concentration, sorption time, state of hydration, and for various delipized tissue specimens. The results indicate rapid uptake of aluminum species in both systems from aqueous solutions for partially hydrated tissue, reaching 50% saturation levels in about 30 min.

Sorption of the various aluminum species depends on the hydration state of the tissue with increases in sorption of 2- to 3 -fold over tissue prehydration timeperiods of 0 -96h. Desorption studies indicate significant reversibility of aluminum chloride sorption from partially hydrated tissue but little desorption from fully hydrated tissue. In contrast, little desorption is observed with aluminum chlorohydrate regardless of tissue hydration levels. Thes differences are interpreted in terms of the inherent physical-chemical properties of the species contained in thes two aqueous aluminum (III) ion systems.