Registration Dossier
Registration Dossier
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EC number: 215-477-2 | CAS number: 1327-41-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- disregarded due to major methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test material
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The sorption of Al complexes to guinea pig stratum corneum has been studied using previously described fluorometric and atomic absorption spectrophotometric procedures. The sorption, desorption, and binding properties of the two aluminum systems most often used in topically applied antiperspirants, aluminum chloride and aluminum chlorohydrate, Al2(OH)5Cl.2H2O were examined as a function of aluminum concentration, sorption time, state of hydration, and for various delipized tissue specimens. The results indicate rapid uptake of aluminum species in both systems from aqueous solutions for partially hydrated tissue, reaching 50% saturation levels in about 30 min.
Sorption of the various aluminum species depends on the hydration state of the tissue with increases in sorption of 2- to 3 -fold over tissue prehydration timeperiods of 0 -96h. Desorption studies indicate significant reversibility of aluminum chloride sorption from partially hydrated tissue but little desorption from fully hydrated tissue. In contrast, little desorption is observed with aluminum chlorohydrate regardless of tissue hydration levels. Thes differences are interpreted in terms of the inherent physical-chemical properties of the species contained in thes two aqueous aluminum (III) ion systems.
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