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Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Generally accepted calculation method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Principles of method if other than guideline:
The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
EC Number:
254-588-0
EC Name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
Cas Number:
39670-09-2
Molecular formula:
C12H22O5
IUPAC Name:
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
Constituent 2
Chemical structure
Reference substance name:
2,2'-ethylenedioxydiethyl dimethacrylate
EC Number:
203-652-6
EC Name:
2,2'-ethylenedioxydiethyl dimethacrylate
Cas Number:
109-16-0
Molecular formula:
C14H22O6
IUPAC Name:
ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(2-methylacrylate)
Details on test material:
- Name of test material (as cited in study report): 2-(2-(2-Ethoxy ethoxy)-ethoxyethyl methacrylate

Test animals

Details on test animals or test system and environmental conditions:
not applicable; in silico modelling

Administration / exposure

Type of coverage:
other: not applicable; in silico modelling
No. of animals per group:
not applicable; in silico modelling

Results and discussion

Absorption in different matrices:
predicted flux 103.508 μg/cm²/h; the relative dermal absorption is high

Any other information on results incl. tables

Based on a molecular weight of 286.32 g/mol and a log Kow of 2.1, the predicted flux of ET3EGMA is 103.508 μg/cm²/h; the relative dermal absorption is high.

Applicant's summary and conclusion

Conclusions:
The dermal absorption of ET3EGMA is predicted to be high; the predicted flux is 103.508 μg/cm²/h.
Executive summary:

The dermal absorption (steady-state flux) of ET3EGMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.

Based on a molecular weight of 246.3 g/mol and a log Kow of 2.1, the predicted flux of ET3EGMA is 103.50 μg/cm²/h; the relative dermal absorption is high.