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EC number: 254-588-0 | CAS number: 39670-09-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Determination of in vitro hydrolysis rates of methacrylate esters; determination of half-lifes in rat liver microsomes and whole rat blood.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- EC Number:
- 254-588-0
- EC Name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- Cas Number:
- 39670-09-2
- Molecular formula:
- C12H22O5
- IUPAC Name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- Reference substance name:
- 2-(2-(2-ethoxy ethoxy)-ethoxyethyl methacrylate
- IUPAC Name:
- 2-(2-(2-ethoxy ethoxy)-ethoxyethyl methacrylate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): ethoxytriethylene glycol methacrylate
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: rat liver microsomes and rat blood
Administration / exposure
- Vehicle:
- DMSO
- Duration and frequency of treatment / exposure:
- 120 min (samples collected at 0, 2, 5, 15, 30, 60 and 120 minutes)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25 mM
- No. of animals per sex per dose / concentration:
- not applicable; in vitro test
- Control animals:
- other: not applicable; in vitro test
- Positive control reference chemical:
- Methyl methacrylate
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Method type(s) for identification: liquid chromatography separation with accurate mass quadrupole/time-of-flight mass spectrometry detection (LC/QTOF-MS) to quantitate methacrylic acid concentrations
- Limits of detection and quantification: LLQ = 0.0117 mM methacrylic acid
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- the ester was rapidly converted to MAA in whole rat blood and rat liver microsomes: half life 4.95 min (liver microsomes) / 27.72 min (blood)
Any other information on results incl. tables
Negative controls in the rat liver microsome experiments included incubations with heat-inactivated microsomes, no microsomes and no NADPH. Removal of NADPH made little or no difference in hydrolysis rates. Heat inactivation significantly reduced hydrolysis rates, and absence of microsomes resulted in no hydrolysis.
ET3EGMA was rapidly converted to MAA in whole rat blood and rat liver microsomes with hydrolysis half-lives of 4.95 min (liver microsomes) and 27.72 min (blood).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: The metabolism data show that ET3EGMA is rapidly hydrolysed in vitro.
The metabolism data show that ET3EGMA is rapidly hydrolysed in vitro. - Executive summary:
This in vitro metabolism study was conducted to investigate in vitro hydrolysis rates of ET3EGMA. Half-lifes were determined in rat liver microsomes and whole rat blood.
ET3EGMA was rapidly converted to MAA in whole rat blood and rat liver microsomes with hydrolysis half lives of 4.95 min (liver microsomes) and 27.72 min (whole blood)
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