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EC number: 941-364-9
CAS number: -
No experimental data
were located on the toxicokinetics of gas oils in vivo, hence
other information sources must be used to assess the toxicokinetics of
these substances in vivo.
experimental studies in animals provide qualitative evidence of
absorption by the lung, as indicated by a modest increase in startle
reflex in rats inhaling respirable aerosols of diesel fuel.
Physico-chemical considerations also suggest that highly respirable
aerosols of poorly water soluble substances with a log Pow greater than
zero will be absorbed to some extent from the respiratory tract. In the
absence of further guidance, it will be assumed that 50% of an inhaled
dose of aerosolised gas oil will be absorbed by animals and humans.
No measured data are
available on the dermal absorption of gas oils, however the occurrence
of systemic tissue changes in repeated dose toxicity studies (in the
absence of dermal irritation, and after controlling for incidental
ingestion during grooming) indicates that some absorption across the
skin is possible. Results from the SKINPERM model indicate that uptake
of gas oil across the skin is likely to be low, with an estimated dermal
flux of 0.0001058 mg cm-2.hour for human skin.
However, the reliability of this value is not known, and therefore
complete absorption of gas oil by human skin has been assumed
(conservative default) as recommended by the TGD (ECB, 2003). This is
probably highly conservative given that the log Pow of the majority
(>98.5%) of gas oil components falls outside the 1-4 range that favours
dermal uptake (ECB, 2003). Since experimental studies demonstrate
greater absorption of lipophilic substances by animal skin compared to
human skin, it will be therefore be assumed during risk characterisation
that animal skin is 2-fold more permeable to topically applied gas oils
than is human skin.
Substance is a
petroleum UVCBs; hence it is not possible to apply standard methodology
for assessing absorption, distribution, and metabolism. Relevant
data for use in risk assessment are available for key constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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