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EC number: 203-615-4 | CAS number: 108-78-1
The Ames Salmonella/Microsome Mutagenicity Test is a bacterial screening test for chemical mutagens causing gene mutations. It is applicable to pure chemicals, complex mixtures and extracts that are soluble in water or organic solvents.
The objective of this study was to determine the mutagenic potential of Melamine. The Plate Incorporation Method of the Ames Salmonella/Microsome Mutagenicity Test was used in this assessment.
No toxicity of the test substance to the bacteria was observed up to 5000 µg per plate in the experiment.
The results of this study indicate that the test article, Melamine, produced no positive mutagenic effect on any of the five Salmonella tester strains under the conditions of the test.
Based on the results of the Plate Incorporation Method of the Ames Salmonella/Microsome Mutagenicity Test, it is concluded that the test article, Melamine, under the conditions of the test, could not be shown to be mutagenic for any of the Salmonella tester strains used in the test, in the presence and absence of an Aroclor 1254-induced rat liver S-9 metabolic activation system.
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