Registration Dossier
Registration Dossier
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EC number: 204-065-8 | CAS number: 115-10-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited reported study
Data source
Reference
- Reference Type:
- publication
- Title:
- Ethers in Anaesthesia
- Author:
- Amiot LG
- Year:
- 1 932
- Bibliographic source:
- Presse Med. 40:300-302
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl ether
- EC Number:
- 204-065-8
- EC Name:
- Dimethyl ether
- Cas Number:
- 115-10-6
- Molecular formula:
- C2H6O
- IUPAC Name:
- dimethyl ether
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- Doses:
- 5 mg/kg
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The test substance is less efficient than diethylether as an anesthetic in animals. It does however have both vasodilator and hypotensor effects. Intraperitoneal doses of 5 mg/kg DME produced reversible anethesia in mice.
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