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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: limited reported study

Data source

Reference
Reference Type:
publication
Title:
Ethers in Anaesthesia
Author:
Amiot LG
Year:
1932
Bibliographic source:
Presse Med. 40:300-302

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl ether
EC Number:
204-065-8
EC Name:
Dimethyl ether
Cas Number:
115-10-6
Molecular formula:
C2H6O
IUPAC Name:
dimethyl ether

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Doses:
5 mg/kg

Results and discussion

Applicant's summary and conclusion

Conclusions:
The test substance is less efficient than diethylether as an anesthetic in animals. It does however have both vasodilator and hypotensor effects. Intraperitoneal doses of 5 mg/kg DME produced reversible anethesia in mice.