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EC number: 231-302-2
CAS number: 7488-55-3
dichloride was tested for its ability to induce chromosome aberrations
in the bone marrow of treated rats according to OECD test guideline 475
and in compliance with GLP.
of Data – Structural Chromosome Aberration Data
of male rats with Tin dichloride for 16 hours resulted in frequencies of
cells with structural chromosome aberrations (excluding gaps) that were
similar to and not significantly (p≤0.05) higher than those observed in
the concurrent vehicle controls for all dose groups. Individual
aberration frequencies for the majority of all Tin dichloride dosed
animals (all dose groups) were similar to those observed in the vehicle
control group and which were consistent with historical vehicle control
data ranges. No statistically significant increase in chromosome
aberrations was observed at a dose of 2000 mg/kg at the 42 hour sample
time with frequencies of cells with structural chromosome aberrations
(excluding gaps) generally similar to values observed within the
concurrent vehicle control group and consistent with historical vehicle
control data ranges. These data indicated no evidence of any test
article dose effect on chromosome aberration induction.
of Data – Numerical Aberration Data
of cells with numerical aberrations for all doses (16 and 42 hour
samples) were similar to those observed within the concurrent vehicle
control groups. Individual numerical aberration frequencies fell within
historical vehicle control range (HCR) data for all treated animals.
is concluded that Tin dichloride did not induce chromosome aberrations
in the bone marrow cells of male treated rats at dose levels of 500,
1000 and 2000 mg/kg (a recommended maximum dose in accordance with
current test regulatory guidelines) following a single oral
administration with sampling at 16 hours (500, 1000 and 2000 mg/kg) or
42 hours (2000 mg/kg) post dose.
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