Tin sulphate

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

no GLP information

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

not specified

Test type:

other: no data

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

oral: drinking water

Vehicle:

water

Doses:

no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 207 mg/kg bw

Interpretation of results:

GHS criteria not met

Remarks:

EU GHS criteria not met

Conclusions:

The LD50 of tin sulfate was determined to be 2207 mg/kg bw.

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 207 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

endpoint for information only

Qualifier:

according to guideline

Guideline:

OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Species:

rat

Strain:

other: HsdHan:WIST strain

Sex:

male/female

Route of administration:

inhalation: dust

Type of inhalation exposure:

nose only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

5, 1, 0.5 mg/L

No. of animals per sex per dose:

6

Control animals:

no

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

2 mg/L air

Based on:

test mat.

Remarks:

dust

Exp. duration:

4 h

Remarks on result:

other: calculated LC50 in accordance with OECD 436

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.5 mg/L air

Based on:

test mat.

Remarks:

dust

Exp. duration:

4 h

Remarks on result:

other: at the dose of 0.5 mg/L no mortality was observed

Remarks:

.

Mortality:

All animals treated at a concentration of 5 mg/L died or were killed in extremis. Two males and one female treated at a concentration of 1 mg/L died or were killed in extremis. All animals exposed to a concentration of 0.5 mg/L survived treatment.

Body weight:

All surviving rats showed a loss in body weight during the first week of the observation period. However, all surviving rats gained weight during the second week of the observation period. All surviving rats, except for two females exposed to a concentration of 1 mg/L had reached their pre-exposure body weight by Day 15.

Gross pathology:

Abnormalities noted at necropsy of animals that that died or were killed in extremis during the study were red, dark, mottled or inflated lungs, pale or dark areas on the lungs, gaseous distension of the stomach, red nasal cavity, white substance in the nasal cavity and small and red thymus. No abnormalities were noted at necropsy of animals killed at the end of the study period except for pale or dark foci on the lungs noted in one female treated at a concentration of 0.5 mg/L.

Interpretation of results:

other: Category 4 based on EU GHS criteria

Conclusions:

The test material was classified as Category 4 in respect of its acute inhalation toxicity according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LC50

Value:

2 mg/L air

Physical form:

inhalation: dust / mist

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because skin contact in production and/or use is not likely

Conclusions:

Substance is irritation to dermis, so no animal test allowed in due to animal protection

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Due to the classification Skin Sens 1 intensive risk management measures are in place to avoid significant skin contact. Hence, a study on dermal toxicity is not performed.