Registration Dossier
Registration Dossier
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EC number: 203-835-0 | CAS number: 111-11-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 78% in 28 days (OECD 301C, Modified MITI Test)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the biodegradation potential of methyl octanoate (CAS No. 111-11-5) are available. Therefore, biodegradation data from a structurally related category member, methyl laurate (CAS No. 111-82-0) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both methyl octanoate and methyl laurate are fatty acid esters esterified with methanol, differing only on the length of the fatty acid C-chain (C8 and C12 respectively). Since the potential for biodegradation is expected to decrease at increasing C-chain lengths, read-across from methyl laurate to methyl octanoate will represent a worst-case scenario for this substance (the biodegradation of C8 will probably be underestimated). Nevertheless, based on the structural similarities between both substances this read-across possibility is justified.
One study evaluating the biodegradation potential of methyl laurate (CAS No. 111-82-0) is available (Japanese Ministry of Economy, Trade and Industry, 1995). In this GLP-study, conducted according to OECD 301C, a mixture of sewage, soil and natural water was used as inoculum and O2 consumption monitored as indicator of biodegradation. After 28 days of incubation, the test substance reached 78% biodegradation. Since the 10-day window concept does not apply to the MITI method, methyl laurate is readily biodegradable according to OECD criteria.
Based on the results obtained for a structurally related category member (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5) methyl octanoate can be considered as readily biodegradable.
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