Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
study conducted in Korea by GLP lab but limited information available in English at this time.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
amporphous glass fibre formed from the melting and fiberisation of predominately slilcon dioxide, calcium oxide, magnesium oxide
EC Number:
610-130-5
Cas Number:
436083-99-7
Molecular formula:
Amorphous glass consisting of SinO(3n-1)2(n-1) Polymeric anions ionically bonded to Ca2+ and Mg2+ cations or other alkaline earth cations
IUPAC Name:
amporphous glass fibre formed from the melting and fiberisation of predominately slilcon dioxide, calcium oxide, magnesium oxide
Details on test material:
- Name of test material (as cited in study report): Isofrax, Carbawool(sic)

Sampling and analysis

Analytical monitoring:
yes
Remarks:
Silica content assessed in test samples using ICP-MS
Details on sampling:
Limited information is available.

Test solutions

Vehicle:
no
Details on test solutions:
loading rate of 100mg/l established in water

Test organisms

Test organisms (species):
Oryzias latipes
Details on test organisms:
TEST ORGANISM
- Common name: Rice Fish
- Strain: Not applicable
- Source:
- Age at study initiation (mean and range, SD): Not specified

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h
Remarks on exposure duration:
Standard as per OECD Guidelines
Post exposure observation period:
None required

Test conditions

Hardness:
Unknown
Test temperature:
Not specified
Salinity:
Not specified
Nominal and measured concentrations:
Nominal: Control and 100 mg/L nominal loading rate
Measured: The dissolved test item may have been one or several components of the test item. Given that toxicity cannot be attributed to a single component or mixture of components but to the test item as a whole, the results were based on nominal loading rates only.
Details on test conditions:
no specific details known at this time conducted in accordance with OECD 203
Reference substance (positive control):
no
Remarks:
Not a guideline requirement

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LL50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (total fraction)
Basis for effect:
mortality (fish)
Details on results:
Mortality: There were no mortalities in fish exposed to a 100 mg/L loading rate for a period of 96 hours.

Sub-lethal effects: There were no sub-lethal effects of exposure observed in fish exposed to a 100 mg/L loading rate for a period of 96 hours.

Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
An estimate of the LL50 values was given by inspection of the mortality data.

Any other information on results incl. tables

Sublethal observations / clinical signs:


no sub lethal observervations reported. 

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
The test was considered to be valid given that none of the control fish died or showed signs of stress during the test.
Conclusions:
The acute toxicity of the test item to the freshwater fish rice fish (Oryzias latipes) has been investigated and gave a 96-Hour LL50 value of greater than 100 mg/L loading rate.