Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: EC JRC validated QMRF and completely fulfilled QPRF, betaine falls within the applicabitility domain of the model.
Justification for type of information:
QSAR prediction

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010
Reference Type:
other: QMRF
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR-modelling following QMRF reported as QPRF
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Betaine
EC Number:
203-490-6
EC Name:
Betaine
Cas Number:
107-43-7
Molecular formula:
C5H11NO2
IUPAC Name:
(trimethylammonio)acetate

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
other: Estrogen receptor binding
Basis for effect level:
other: The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore, it can be concluded that the test substance does not bind Estrogen receptor B.

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.
Executive summary:

The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.