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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15.4.1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
The study was performed with a modified OECD method 107. Instead of three replicates, results were calculated using only one measurement.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
yes
Remarks:
The results were calculated only from one flask-shaking measurement.
Principles of method if other than guideline:
Modified from OECD guideline method 107. The amounts of analytes after shaking were analysed by HPLC. The results were calculated from one flask-shake measurement.
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
Pow
Partition coefficient:
<= 0.001
Temp.:
20 °C
Remarks on result:
other: pH not available
Type:
log Pow
Partition coefficient:
<= -3.1
Temp.:
20 °C
Remarks on result:
other: pH not available
Conclusions:
The water/n-octanol partition coefficient of the substance was determined by using a modified version of OECD guideline method 107. The amounts of analytes after shaking in both phases were determined by using HPLC. The repeatability of injection before analyses was acceptable. The results were calculated only from one flask-shaking measurement. The pH-value was not available nor documented in the analysing report.

Pow of the substance at 20 C was 0.00081.
Executive summary:

The water/n-octanol partition coefficient of the substance was determined by using a modified version of OECD guideline method 107. The amounts of analytes after shaking in both phases were determined by using HPLC. The repeatability of injection before analyses was acceptable. The results were calculated only from one flask-shaking measurement. The pH-value was not available nor documented in the analysing report.

Pow of the substance at 20 C was 0.00081.

Description of key information

Determined by using a modified OECD guideline method 107. The analysis was performed by HPLC, and the study was performed at the manufacturer's laboratory using best practice found.

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.1
at the temperature of:
20 °C

Additional information