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Description of key information

Humans: 0.035mg/cm2/hr (damage ratio 2.0+/-1.0)
Humans: 0.29mg/cm2/hr (damage ratio <1.0)
Rat: 0.51mg/cm2/hr (damage ratio 1.9)

Key value for chemical safety assessment

Additional information

An in vitro dermal absorption study using rat skin showed that 2 -(2 -butoxyethoxy)ethanol is able to pass through full thickness rat skin at a rate of 0.51mg/cm2/hr and can cause slight but significant permanent damage (increased permeability - damage ratio 1.9).

Two in vitro dermal absorption studies using human skin showed that 2 -(2 -butoxyethoxy)ethanol is able to pass through the stratum corneum but gave somewhat conflicting permeation results of 0.29 and 0.035mg/cm2/hr at a slow rate (35ug/cm2/hr). Both did however show that permanent damage is low to insignificant and that there is a lag time of approximately 2 hours for substance to cross the skin and appear in the receptor fluid. Since the higher result is alsomore recent and obtained using radiolabelled material, it should be used in preference. These results do confirm that the permeation rate in humans is less than rats; a conservative factor of 2 can be used.

A QSAR value of 0.35mg/cm2/hr is also available; this is consistent with the measured data.