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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study report not reviewed. Included for completion from a secondary source. Since the paper ruled out the substance as being the cause of the effects seen, further analysis of the study was not deemed necessary.

Data source

Reference
Reference Type:
publication
Title:
Arbeitsmedizinish-toxikologische Beurteilung von butylglykol und anderen Inhaltsstoffen von Tepetenfarben
Author:
Thies Von AM, Hofmann HT, Elschnig G
Year:
1997
Bibliographic source:
Zbl Arbeitsmed 27, 2-6

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
no data
GLP compliance:
no
Remarks:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Substance contained in a water based paint.

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 2
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
accidental
Exposure assessment:
estimated

Results and discussion

Clinical signs:
Nephrotoxicity and hepatotoxicity reported.

Applicant's summary and conclusion

Conclusions:
The poisoning incident could not be attributed to exposure to 2-(2-butoxyethoxy)ethanol
Executive summary:

Two patients reported liver and kidney damage following inhalation absorption of 2 -(2 -butoxyethoxy)ethanol from the use of paint containing the solvent. A detailed investigation of case lead to the conclusion that the reported effects were almost certainly unrelated to solvent exposure.