Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Vasquez RE (2012) investigated the sensitising properties of NMMO 50% in a Buehler test with male and female Hartley guinea pigs. The study examined the skin sensitising effect on guinea pigs: 4 for primary irritation (dose range), 20 for test article group (10 male/10 female), 10 for vehicle control group (5 male/5 female) and 6 for positive control group (3 male/3 female).

Positive and vehicle controls were included in the study. Animals were induced and challenged with the commercial NMMO (as received, i.e. 50%). Under the conditions of this study, induction with NMMO (n-Methylmorpholine Oxide 50%) as received did not elicit a delayed contact hypersensitivity response in guinea pigs when challenged as received.

Migrated from Short description of key information:
In a Buehler test according to OECD Guideline 406, NMMO proved not to be sensitising to the skin (Vasquez RE, 2012).

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

According to the criteria of the DSD and CLP Regulation, NMMO should not be classified as sensitising to the skin.