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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
e-Caprolactam
Author:
Goldblatt M.W. et al.
Year:
1954
Bibliographic source:
Brit. J. Ind. Med. 11, 1-10

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Patch test with 6 volunteers was performed using 5% solution of Caprolactam.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Caprolactam

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 6
- Sex: 4 males and 2 females
- Race: one fair girl, one dark girl, two fair men, two dark men
Details on study design:
TYPE OF TEST(S) USED: patch test


ADMINISTRATION
- Vehicle / solvent: water
- Concentrations: 5 %
- Removal of test substance: after 48 h

Results and discussion

Any other information on results incl. tables

No irritant effects of any kind were produced. Similar experiments were carried out with a 5% olive oil solution of e-caprolactan, and again it was found with five subjects that no irritant effects were produced during four days of application twice a day.

Applicant's summary and conclusion