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EC number: 242-060-2
CAS number: 18172-67-3
The determination of the 48h-EC50 (Daphnia magna) of (-)-beta-pinene is based on two experimental studies and one QSAR.Measured and estimated data ranging from 1.250 mg/L to 1.09 mg/L. A key value is calculated as the geometric mean of the three values: 48h-EC50=1.194 mg/L.
Two experimental studies and one QSAR are
available to determine the 48h-EC50 (Daphnia magna) of
In an acute aquatic toxicity study
performed similarly to OECD guideline 202, groups (15 daphnids per
concentrations) of Daphnia magna were exposed to (-)-beta-pinene
at concentrations of 0, 390, 780, 1170, 1560 and 1950 µg/L (nominal) for
48 hours under flow-through conditions.
The 48h-EC50 was determined
to be at 1.250 mg/L (based on measured concentrations of the test item).
The 48hr acute toxicity of
(-)-beta-pinene to Daphnia magna was studied under semi-static
conditions. Daphnids were exposed to control, and test chemical at
nominal test concentrations of 1.0, 1.4, 2.1, 2.9, 4.2 mg/L and at a
concentration close to the solubility limit of the test item in the test
water for 48 h. The 48h-EC50 was 1.248 mg/L.
A QSAR prediction was performed to
assess the acute toxicity of the test item β-pinene to daphnid. This
QSAR has been validated to be compliant with the OECD recommendations
for QSAR modeling (OECD, 2004) and predicts the endpoint value which
would be expected when testing the substance under experimental
conditions in a laboratory following Guideline for Testing of Chemicals
No. 202, "Daphnia sp., Acute Immobilisation Test", referenced as Method
C.2 of Commission Regulation No. 440/2008. The 48h-EC50 is
predicted as 1.09 mg/L.
The 48h-EC50 (Daphnia magna)
calculated as the geometric mean of these three results can be used as
key value for chemical safety assessment.
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