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Reaction mass of 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] and 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2-methylphenyl)-3-oxobutyramide] and 2-[[3,3'-dichloro-4'-[[1-[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1'-biphenyl]-4-yl]azo]-3-oxo-N-(o-tolyl)butyramide
EC number: 911-715-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Objective of study:
- other: bioavailability of hypothetical cleavage products
- Principles of method if other than guideline:
- investigation of urinary excretion of a hypothetical cleavage product of the test item after oral application
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-[[2-chloro-4-[3-chloro-4-[[1-(2,4-dimethylphenylamino)-1,3-dioxobutan- 2-yl]diazenyl]phenyl]phenyl]diazenyl]-N-(2-methylphenyl)-3-oxobutanamide
- EC Number:
- 911-715-0
- Molecular formula:
- C36H34Cl2N6O4 // C35H32Cl2N6O4 // C34H30Cl2N6O4
- IUPAC Name:
- 2-[[2-chloro-4-[3-chloro-4-[[1-(2,4-dimethylphenylamino)-1,3-dioxobutan- 2-yl]diazenyl]phenyl]phenyl]diazenyl]-N-(2-methylphenyl)-3-oxobutanamide
- Reference substance name:
- Pigment Yellow 174
- IUPAC Name:
- Pigment Yellow 174
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAI f (SPF)
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil (no further information)
- Duration and frequency of treatment / exposure:
- single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 40, 400 mg/kg
- No. of animals per sex per dose / concentration:
- The test was performed with 30 male rats, not indicated how many animals were investigated per substance and dose group
- Control animals:
- yes
- Positive control reference chemical:
- 3,3'-dichlorobenzidine
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- - No 3,3'-dichlorobenzidine metabolites were detected in the urine collected after administration of the test item.
Any other information on results incl. tables
- animals receiving 3,3'-dichlorobenzidine excreted 2-4% of the administered dose within 24 hours and additional 0.2-1% between 24 and 48 hours after application
- limit of detection: 5 µg/l urine
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: no indication for a metabolic spllitting of the pigment into 3,3'-dichlorobenzidine
No 3,3'-dichlorobenzidine was detectable in the urine of rats after oral application, which indicates that the test item is not splitted into 3,3'-dichlorobenzidine after oral application. - Executive summary:
Single oral application of 40 or 400 mg test item/kg bw to male rats did not result in the excretion of 3,3'-dichlorobenzidine in the urine during 48 hours after exposure. After application of 3,3'-dichlorobenzidine about 2 -4% of the applied dose was detected in the urine excreted within 24 hours after application.
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