Registration Dossier
Registration Dossier
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EC number: 282-758-4 | CAS number: 84402-58-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2003-11-01 till 2004-03-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- EC Number:
- 282-758-4
- EC Name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- Cas Number:
- 84402-58-4
- Molecular formula:
- C2H6N4O.CH5O3P
- IUPAC Name:
- Phosphonic acid, P-methyl-, compd. with N-(aminoiminomethyl)urea (1:1)
- Details on test material:
- technical product
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 2x3 female rats, one dose
- Control animals:
- no
- Statistics:
- not necessary
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: All animals were found normal throughout the experimental period.
- Gross pathology:
- External examination of animals did not reveal any lesion of pathological significance.
No treatment related effects were observed in any animal at any steps.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 dose of the test material in Wistar rats is 2000 mg/kg bw. According to GHS (Globally Harmonized Classification System) the test item was classified into Category 5 (LD50 cut-off: unclassified).
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