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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012-02-09 till 2012-08-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with GLP and without any deviation
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Remarks on exposure duration:
Results for 72 h and 96 h
Post exposure observation period:
No
Hardness:
Calculated water hardness of the test water: 0.24 mmol/L (= 24 mg/L) as CaCO3.
Salinity:
No
Reference substance (positive control):
no
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
43.1 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks on result:
other: 40.8-45.4 mg/L
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
13.5 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks on result:
other: 12.0-14.9 mg/L
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks:
and biomass
Remarks on result:
other: determined
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
47.5 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks on result:
other: 45.9-49.0 mg/L
Duration:
96 h
Dose descriptor:
EC10
Effect conc.:
16.3 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks on result:
other: 15.2-17.4 mg/L
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Remarks:
and biomass
Remarks on result:
other: determined
Validity criteria fulfilled:
yes
Conclusions:
The algae has been shown to be the most sensitive freshwater organism. The 72h-ErC10 = 13.5 mg/L (nominal), and the 72h-(96h)-NOEC = 3.2 mg/L (nominal) for the active substance.

Description of key information

The  active substance  is not acute toxic to algae at a nominal concentration of 3.2 mg/L in a static aquatic toxicity test performed for 72 hours.

Key value for chemical safety assessment

EC50 for freshwater algae:
43.1 mg/L
EC10 or NOEC for freshwater algae:
3.2 mg/L

Additional information

The algae Pseudokirchneriella subcapitata has been shown to be the most sensitive freshwater organism.

72h-ErC10 = 13.5 mg/L (nominal),

72h-(96h)-NOEC = 3.2 mg/L (nominal).

These aquatic acute and chronic toxicity values do not lead to a classification of the substance.

Therefore no additional chronic aquatic toxicity tests seem to be necessary for the active substance.