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EC number: 259-160-7 | CAS number: 54423-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an U.S.E.P.A. TSCA Testing Guideline with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4500 (Acute Eye Irritation)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Healthy young adult rabbits were obtained from J. Leslie Furs, American Fork, Utah with a body weight of 2.0 — 4.0 kg before dosing. The rabbits were acclimated for 7 days before being placed on study. The animals were Individually housed in stainless steel, wire mesh bottom cages. Animal room air was 100% fresh with not less than 10 air changes per hour. The temperature was maintained within the protocol limits of 61 — 70°F and the relative humidity ranged from 40 — 60%. Lighting was 12/12 hour, light/dark cycle. Fresh certified Agway rabbit feed was provided ad libitum and Fresh potable water was provided ad libitum.
.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 5 male, 1 female
- Details on study design:
- left eye was used as control.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 and 72 hours post-treatment.
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 72 hr
- Irritant / corrosive response data:
- At the 1 hour scoring period, conjunctival redness (Mean = 1.5), chemosis (Mean = 1.8) and discharge (Mean = 1.5) were observed in all six animals.
At the 24 hour scoring period, conjunctival redness (Mean = 0.2) and discharge (Iiean = 0.2) were observed in one of the six animals. At the 48 and 72 hour scoring periods, all animals were free of ocular lesions.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based upon the average irritation score of 0.3 calculated for the six animals using the 24 and 72 hour readings, vinyl neononanoate is considered to be a Mild Irritant under the conditions of this test.
- Executive summary:
Vinyl neononanoate was evaluated for eye irritation potential by an U.S.E.P.A. O.T.S. Acute eye Irritation Testing Guideline study in compliance with the GLP regulations. Based upon the average irritation score of 0.3 calculated for the six rabbbits using the 24 and 72 hour readings, vinyl neononanoate is considered to be a Mild Irritant under the conditions of this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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