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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects up to the limit of water solubility for Brachydanio rerio (OECD 203)

Key value for chemical safety assessment

Additional information

Since no studies are available on the short-term fish toxicity of 2-ethylhexyl laurate (CAS No. 20292-08-4), the assessment was based on studies conducted with the structurally most similar substances, for which data is available, dodecanoic acid hexyl ester (CAS No. 34316-64-8) and dodecanoic acid isooctyl ester (CAS No. 84713-06-4). as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

The key study with dodecanoic acid isooctyl ester (CAS No. 84713-06-4) was performed according to OECD guideline 203 and GLP (Bogers, 1997). The test organism Cyprinus carpio was exposed to the test substance in a static system for 96 hours, at the nominal test concentration of 10,000 mg/L. Only the separated water phase was used in the test solutions. No mortality occurred at any of the test concentrations, and the LC50 was reported to be above 10,000 mg/L.

The supporting study conducted with dodecanoic acid hexyl ester (CAS No. 34316-64-8) was performed according to the guideline ISO 7346-1 (similar to OECD 203), in a semi-static system, using Brachydanio rerio as test organism (Guhl, 2005). The fish were exposed to nominal test concentrations of 100, 300, 700, 1000, 3000 and 10000 mg/L during 96 hours. Significant mortality occurred at the two highest test concentrations, and an LC50 of 2200 mg/L was derived. However, the test concentrations in this study were far above the saturation limit of the test substance, and undissolved test material was not removed from the test solutions. The sudden increase in mortality from 0% at concentrations 100 – 1000 mg/L to 70% at 3000 mg/L is better explained by a physical effect, caused by the amount of undissolved material in the test solution, rather than a systemic toxic effect. It is therefore probable that no toxic effects occurred up to the limit of water solubility of the test substance.

Thus, based on theabove mentioned results, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up tothe limit ofwater solubility for 2-ethylhexyl laurate (CAS No. 20292-08-4).