Registration Dossier
Registration Dossier
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EC number: 618-882-6 | CAS number: 928771-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published data, information included to support waiver
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of n-C9 to n-C13 alkanes in the rat on short term inhalation
- Author:
- Nilsen, OG, Haugen, OA, Zaglsen, K et al.
- Year:
- 1 988
- Bibliographic source:
- Pharmacology and Toxicology 62, 259-266
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Animals were exposed to vapour for 8-hr followed by a 14-d post-observation period.
- GLP compliance:
- not specified
- Test type:
- other: adaptation of standard method (8-hr exposure)
- Limit test:
- no
Test material
- Reference substance name:
- n-nonane (n-C9)
- IUPAC Name:
- n-nonane (n-C9)
- Reference substance name:
- n-decane (n-C10)
- IUPAC Name:
- n-decane (n-C10)
- Reference substance name:
- n-undecane (n-C11)
- IUPAC Name:
- n-undecane (n-C11)
- Reference substance name:
- n-dodcane (n-C12)
- IUPAC Name:
- n-dodcane (n-C12)
- Reference substance name:
- n-tridecane (n-C13)
- IUPAC Name:
- n-tridecane (n-C13)
- Details on test material:
- All test samples had an analysed purity (GC) of 99.6-99.9%
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard A/S, Ll. Skensved, Denmark
- Weight at study initiation: 180-220 g
- Acclimation period: 4-6 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- Exposure system: conical 0.7 m3 steel chambers with glass front door and walls; flow rate 30-40 l/min.
Vapour generation: test substance warmed (approx. 22 degrees C) under negative pressure and mixed with clean air to achieve required concentration
Analytical verification of achieved concentration: concentration in chamber air monitored automatically every 15 min using on-line GC-FID (Shimadzu GC-9A; 2 m x 1/8” column containing 10% SP-2100 on Supelcoport 100/120 mesh; helium carrier gas)
Standards: authentic standards processed in parallel
Aerosol: presence in chamber air quantified using a Royco 241 aerosol particle counter
Vapour:aerosol ratio: 3.04 x 10 e-6 for tridecane - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 8 h
- Concentrations:
- n-C9: 5280*, 4438, 3560 and 2414 ppm
n-C10: 1369* ppm
n-C11: 442* ppm
n-C12: 142* ppm
n-C13: 41* ppm
Values marked * were the maximum achievable vapour concentration in air - No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- Animals were exposed to at least the saturated vapour concentration (20 degrees C) for each test substance for 8 hr followed by a full gross necropsy on day 14. The LC50 for n-nonane was calculated by probit analysis.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4 467 ppm
- Based on:
- test mat.
- Remarks:
- n-nonane
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality for n-decane, n-undecane, n-dodecane or n-tridecane at maximum saturated vapour concentration in air
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 1 369 ppm
- Based on:
- test mat.
- Remarks:
- n-decane
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality at saturated vapour concentration
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 442 ppm
- Based on:
- test mat.
- Remarks:
- n-undecane
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality at saturated vapour concentration
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 142
- Based on:
- test mat.
- Remarks:
- n-dodecane
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality at saturated vapour concentration
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 41
- Based on:
- test mat.
- Remarks:
- n-tridecane
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality at saturated vapour concentration
- Mortality:
- n-nonane: 0/10, 1/10, 4/10, 9/10 at 2414, 3560, 4438 and 5280 ppm, respectively
n-decane, n-undecane, n-dodecane, n-tridecane: no mortality at maximum saturated vapour concentration
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute inhalation LC50 for n-nonane was 4467 ppm (23.4 mg/l) following 8-hr exposure.
- Executive summary:
The acute inhalation toxicity of a series on C9-C13 n-alkanes was investigated in male SD rats following a single 8-hr exposure to vapour. A calculated LC50 of 4467 ppm (23.4 mg/l) was determined for n-nonane; the 4 -hr LC50 value is likely to exceed this value. No mortality was recorded for the other test substances after exposure to the maximum achievable vapour concentration in air. Maximum saturated vapour concentration decreased in a predictable manner with increasing C-number.
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