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Long-term toxicity to aquatic invertebrates

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Description of key information

Long-term toxicity of the test material toward an aquatic invertebrate was determined in GLP compliant laboratory according to OECD Guidelines for Testing Chemicals (1998) no 211 "Daphnia magna, Reproduction test". The 14 and 21 Day EL50* (immobilisation) values for parental generation were estimated to be greater than 100 mg/l WAF. The 21 Day EL50* (reproduction) value was estimated to be greater than 100 m/l WAF. The LOEC was considered to be 3.2 mg/l WAF on the basis that at this loading rate significantly (p < 0.05) fewer youngs per adult were produced when compared to the control. The NOEC was considered to be 1 mg/l WAF on the basis that at this loading rate there were no significant mortalities (immobilisation) observed in the parental generation and that there were no significant (p > 0.05) differences between the control and the 1.0 mg/l loading rate WAF test group in terms of numbers of live young produced per adult by Day 21.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 mg/L

Additional information

Due to poor water solubility of the substance, the organisms were exposed to a Water Accommodated Fraction (WAF) of the test substance. This is a commonly accepted procedure for regulatory studies on poorly water soluble substances.