Registration Dossier
Registration Dossier
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EC number: 500-199-9 | CAS number: 68183-39-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is an UVCB generated by the reaction of glycerol, propane-1,3-diol and trimellitic anhydride. It is expected that the starting materials or their hydrolysis products are released in the course of metabolism. Esterases present in the skin, in the interstinal tissues and in liver and plasma can efficiently cleave similar esters.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 1
- Absorption rate - inhalation (%):
- 100
Additional information
The dermal absorption has been modeled according to Fitzpatrick et al.. The log Kp calculated with a mol wt. of 920 and a logKow of 0.3 is -12.2 indicating a marginal potential for skin penetration.
D. Fitzpatrick, J. Corish, B. Hayes: Modelling skin permeability in risk assessment–the future. Chemosphere 55 (2004) 1309–1314
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