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EC number: 203-865-4 | CAS number: 111-40-0
During the reproduction study no mortality occurred that could be ascribed to the administration of DETA. Data obtained through clinical obsevations, and macroscopic and microscopic examinations, revealed no effects of the treatment. Food consumption data showed a statistically significant decrease in the females of the 300 mg/kg bw group during the first week of the study. High dose male body weight was decreased from day 0 -28 and high dose female body weight gain was decreased during premating and during the gestation period (days 0 -21). The no-adverse-effect level for parental toxicity is 100 mg/kg bw/day.
Most mating and litter data like precoital time, mating index, fertility index, number of live and dead pups, showed no adverse effects of the treatment. Maternal performance of the females in the 100 mg/kg and 300 mg/kg bw DETA groups were affected: duration of gestation was increased in a dose-related way. Due to the relatively post-implantation loss the mean litter size was reduced in the mid and high dose group. The no-adverse-effect level for reproduction and development is 30 mg/kg bw per dy.
Pup body weights and clinical and necropsy observations did not reveal any reaction to the treatment.
Diethylenetriamine (DETA) was administered by gavage to male and female Wistar rats at levels of 0, 100, 300, 500 and 1000 mg/kg b.w. during 7 days to set dose levels for a reproduction/developmental toxicity screening study (OECD draft guideline no. 421). Animals in the 1000 mg DETA group showed a severe reaction to the treatment, as indicated by the mortality rate and macroscopic observations. Animals in the 500 mg DETA group showed a moderate reaction as concluded from pathological examination and decreased body weight. For the reproduction/developmental study levels of 30, 100 and 300 mg/kg b.w./day were chosen.
Diethylenetriamine was administered daily by gavage to male and female Wistar rats at levels of 30, 100 and 300 mg/kg b.w. during a 2-week premating period, and during mating and gestation up to day 4 post partum or at least during a 4-week period, to screen its effect on male and female reproductive performance and on the development of the offspring.
During the reproduction study no mortality occurred that could be ascribed to the administration of DETA. Data obtained through clinical observations, and macroscopic and microscopic examinations, revealed no effects of the treatment.
Mean parental body weights of both males and females in the 300 mg/kg b.w. DETA group were slightly decreased when compared to the control values. Body weight change of the males of the 300 mg DETA group was statistically significantly decreased when compared to the males from the control group from days 0-28. For the females of this high dose group body weight change during the premating period (days 0-14) and during gestation (days 0-21) showed a statistically significantly decrease when compared to the control females in both periods.
Food consumption data showed a statistically significant decrease in the females of the 300 mg/kg b.w. DETA group.
Maternal performance of the females in the 100 mg and 300 mg/kg b.w. DETA groups were affected: duration of gestation was increased statistically significantly, and post-implantation loss was increased in a dose-related way.
No adverse effects were observed concerning the general health and the body weights of the pups.
On the basis of the results obtained it can be concluded that:
- Diethylenetriamine (DETA), when administered by gavage for 4 weeks, causes a light parental toxicity at levels of 300 mg/kg b.w. Consequently, the no-adverse effect level for parental toxicity as established in this study is 100 mg/kg b.w. per day.
- In view of the reproduction effects, the no-adverse effect level for reproduction and development is 30 mg/kg b.w. per day.
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