Registration Dossier

Administrative data

Description of key information


Skin Irritation: There was one key study and one supporting study identified regarding the skin irritation potential of diethylene triamine in rats.
Eye Irritation: There was one key study and one supporting study identified concerning the eye irritation potential of diethylene triamine on the rabbit eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The two studies indicate severe skin damage after treatment with diethylene triamine. After one minute of exposure, skin appeared partly necrotic with marginal reddening.

Two studies indicated severe irreversible corneal damage up through 8 days of observation post-administration with DETA in both washed and unwashed eyes.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly corrosive

Justification for classification or non-classification

DETA has a GHS classification as a Category 1B skin irritant based on the Annex 6 classification.


DETA has a GHS classification as a Category 1 eye irritant.