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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to guideline and/or standard method but was non-GLP. Meets basic scientific principles.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Rats are orally gavaged and observed for 14 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-iminodi(ethylamine)
EC Number:
203-865-4
EC Name:
2,2'-iminodi(ethylamine)
Cas Number:
111-40-0
Molecular formula:
C4H13N3
IUPAC Name:
N-(2-aminoethyl)ethane-1,2-diamine
Details on test material:
- Name of test material (as cited in study report): Diethylenetriamine

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: reared in our own colony
- Age at study initiation: 3 to 4 weeks
- Weight at study initiation: 90-120 grams
- Fasting period before study: no

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Test material was delivered undiluted by oral gavage.
Doses:
1.0, 2.0 and 4.0 ml/kg
No. of animals per sex per dose:
Five
Control animals:
no
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1.62 mL/kg bw
Remarks on result:
other: 1.18 to 2.24 ml/kg range
Mortality:
4.0 ml/kg: 5/5 dead - Days to Death 0, 0, 1, 1, 1
2.0 ml/kg: 4/4 dead - Days to Death 2, 3, 7, 8



Clinical signs:
4.0 ml/kg; Sluggish 2 min; prostrate 3 hr; death of 2 at 4 hour
2.0 ml/kg: Sluggish 10 min
Body weight:
No data
Gross pathology:
In victims, petechial hemorrhages of the lungs; stomachs liquid filled, hemorrhaged; intestines liquid-filled, opaque, hemorrhaged, slightly yellow; kidneys and adrenals slightly congested; kidneys speckled; livers and spleens mottled. Nothing remarkable in survivors.
Other findings:
No data

Any other information on results incl. tables

Diethylenetriamine was moderately toxic following single stomach intubation.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The acute oral LD50 of DETA in rats is 1.62 ml/kg (using the density value of 958.6 kg/m3 (IUCLID section 4.4), this corresponds to 1553 mg/kg).
Executive summary:

The acute oral toxicity of DETA was examined in rats. The acute oral LD50 of DETA in rats is 1.62 ml/kg. Using the density value of 958.6 kg/m3 (IUCLID section 4.4), this corresponds to 1553 mg/kg.