Registration Dossier
Registration Dossier
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EC number: 231-714-2 | CAS number: 7697-37-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
A qualitative judgement on the toxicokinetic behaviour based on physico-chemical characteristics is done following the recommendations of ECHA (ECHA Endpoint specific guidance, Chapter R.7c; section R.7.12.2.1).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 50
Additional information
A qualitative judgement on the toxicokinetic behaviour was performed based on physico-chemical characteristics. Nitric acid is an inorganic substance and thus some physico-chemical characteristics (like the octanol/water partition coefficient) are not defined, limiting the possibilities of a qualitative assessment. Absorption factors of 100% are proposed for oral, inhalation and dermal absorption. For route-to-route extrapolation starting from oral data, an absorption factor of 50% is proposed as a worst-case assumption. Nitrate can be reduced to nitrite by both enteric bacteria and mammalian nitrate reductase activity. Nitric acid is not considered to have bioaccumulative potential as nitrate is highly soluble in water and rapidly excreted via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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