Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: no data
GLP compliance:
no
Species:
rat
Route of administration:
oral: unspecified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
7 060 mg/kg bw
Remarks on result:
other: range: 5780-8630 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
7 060 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: no data
GLP compliance:
no
Species:
rat
Route of administration:
inhalation: vapour
Duration of exposure:
4 h
Concentrations:
saturated vapour
Sex:
not specified
Dose descriptor:
LC0
Exp. duration:
4 h
Remarks on result:
other: saturated vapour
Sex:
not specified
Dose descriptor:
LC50
Effect level:
4 000 ppm
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: For TEOF an effect level of 4000 ppm equals 24750 mg/m3 at 21 degrees C and 760 mm HG atmospheric pressure
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
24 570 mg/m³ air

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: no data
GLP compliance:
no
Species:
rabbit
Sex:
not specified
Dose descriptor:
LD50
Effect level:
18 000 mg/kg bw
Based on:
test mat.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
18 000 mg/kg bw

Additional information

Justification for classification or non-classification

At the reported LD50 levels there is no requirement for an acute toxicity classification