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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-10-08 to 2014-10-10
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed in accordance with standard test protocols (OECD 104 resp. EU A.4) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Remarks:
weight loss
Temp.:
20 °C
Vapour pressure:
5.81 Pa
Temp.:
25 °C
Vapour pressure:
8.83 Pa
Transition / decomposition:
no

The vapour pressure of nicotine was determined through weight loss in an effusion cell according to Knudsen. The measurement was performed at 30 °C, 40 °C, and 50 °C.

T [°C]

T [K]

p [Pa]

Standard deviation

p [Pa]

Relative standard deviation

p [%]

30.0

303.2

13.1

0.39

3.0

40.0

313.2

29.6

4.88

16.5

50.0

323.2

58.1

3.58

6.2

The vapour pressure was calculated from

p = [m/(K·A·t)] · [(2·π·R·T)/M]1/2

with

p

vapour pressure to be determined [Pa]

m

weight loss [kg]

t

time [s]

A

area of aperture = 1.96 · 10-7m2

K

correction factor = 0.834

R

8.3144 J/(mol·K)

T

temperature [K]

M

molecular weight of test item = 0.1622 kg/mol

To determine the vapour pressure of nicotine at 20 °C and 25 °C, the common logarithm of the measured vapour pressure (log p) was plotted against 1/T. The data were fitted by linear regression:

y = -3174.3 · x + 11.593; r = -0.9994; r2= 0.9987

with

y

log p; [p] = Pa

x

1/T; [T] = K

r

correlation coefficient

r2

coefficient of determination

From the regression equation, the following vapour pressures were calculated:

Vapour pressure at 20 °C: 5.81 Pa

Vapour pressure at 25 °C: 8.83 Pa

Conclusions:
The vapour pressure of the test item nicotine was determined at three different temperatures (30 °C, 40 °C, and 50 °C) according to EU method A.4 (effusion method; weight loss).
All experiments showed good reproducibility, giving relative standard deviations of less than 17 % and good correlation. Therefore, the result of the test can be considered valid.
Executive summary:

The vapour pressure of nicotine was determined according to EU method A.4 (effusion method; weight loss).

The vapour pressure was examined at three different temperatures (30 °C, 40 °C, and 50 °C). The common logarithm of the measured vapour pressure (log p) was plotted against 1/T. The data were fitted by linear regression with a correlation coefficient of -0.9994.

For the test item nicotine, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:  5.81Pa

Vapour pressure at 25 °C:  8.83Pa

Description of key information

Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.

Key value for chemical safety assessment

Vapour pressure:
5.81 Pa
at the temperature of:
20 °C

Additional information