Registration Dossier

Physical & Chemical properties

Density

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
relative density
Remarks:
Other density types indicated (migrated information): density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-09-22 to 2014-09-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed in accordance with standard test protocols (OECD 109 resp. EU A.3) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.3 (Relative Density)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
pycnometer method
Type:
density
Density:
1.01 g/cm³
Temp.:
20 °C
Type:
relative density
Density:
1.01
Temp.:
20 °C

Results of the single determinations with the respective error:

Determination

Density [g/cm3]

Error of Determination [g/cm3]

1

1.0097

0.0001

2

1.0100

0.0001

The density of the test item nicotine was calculated from

ρ = [(m3– m1) / (m2– m1)] · ρH2O

with

ρ

density of test item to be calculated [g/cm3]

m1

mass of empty pycnometer [g]

m2

mass of pycnometer filled with water [g]

m3

mass of pycnometer filled with test item [g]

ρH2O

density of water at test temperature (0.9982 g/cm3at 20.2°C)

The error of each determination method was calculated from Δρ= (2·Δm·100%) / (m3– m1) + (2·Δm·100%) / (m2– m1) with

Δρ

relative error of measured density

Δm

absolute error of single weighing

m1

mass of empty pycnometer [g]

m2

mass of pycnometer filled with water [g]

m3

mass of pycnometer filled with test item [g]

Mean values and standard deviations of the determined parameters:

Parameter

Value

Unit

Standard Deviation

Relative Standard Deviation

volume of pycnometer

10.81

cm3

0.0028

0.03 %

density of test item nicotine

1.0099

g/cm3

0.0002

0.02 %

density of test item nicotine

1009.9

kg/m3

0.2

0.02 %

relative density of test item nicotine

1.0099

 

0.0002

0.02 %

Conclusions:
The density of nicotine corresponds to 1.0099 ± 0.0002 g/cm³ at 20.0 ± 0.4 °C. This value is the mean of two independent determinations ± the standard deviation. The standard deviation shows good correlation of the two determinations.
Therefore, the study is considered valid.
Executive summary:

The density of nicotine has been determined by the pycnometer method and corresponds to

1.0099 ± 0.0002 g/cm3at 20.0 ± 0.4 °C.

Description of key information

Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.

Key value for chemical safety assessment

Relative density at 20C:
1.01

Additional information